Congratulations to Shimon Sakaguchi, Mary Brunkow, and Fred Ramsdell, the 2025 Nobel Laureates in Physiology or Medicine, for discoveries that revealed how the immune system maintains balance. Their work uncovered regulatory T cells (Tregs) and the FOXP3 gene, showing that immune tolerance is an active, gene-driven process essential for preventing autoimmunity and shaping today’s immunotherapy strategies.

Bio X Cell’s in vivo functional grade antibodies are engineered to support foundational discoveries in immune tolerance, Tregs, and FOXP3 biology. Key antibodies cited the field of immune tolerance include:

  • Anti-CD25 (PC61) (BE0012): Regulatory T cell studies
  • Anti-CD4 (GK1.5) (BE0003-1): T cell characterization
  • Anti-CTLA-4 (9H10 (BE0131), BN13 (BE0237), or Ipilimumab biosimilar (SIM0004): Immune checkpoint pathways
  • Anti-PD-1 (RMP1-14 (BP0146), 29F.1A12 (BE0273), J43 (BE0033-2)): Checkpoint and tolerance research

We applaud the achievements of this year’s Nobel Laureates and express gratitude to the many scientists whose work continues to expand the frontiers of immunology.

View the official announcement for the Nobel Prize in Physiology or Medicine 2025 award.