Advanced Antibody Engineering
Sequence-defined antibody engineering services designed to adapt format, function, and expression for in vivo and translational research needs.
Bio X Cell supports antibody modification starting from provided sequences or DNA, enabling study-aligned constructs without entering discovery or target identification.
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Bio X Cell is Easy
Bio X Cell applies a structured, scientist-led approach to antibody engineering services, focused on technical alignment, defined constructs, and reliable execution.
Each step is designed to deliver sequence-defined, study-ready antibodies, that support reproducibility, program continuity, and translational decision making.
Engineering Capabilites At-A-Glance
Overview of standard antibody engineering capabilities and optional study-aligned enhancements available through Bio X Cell.
| Phase | Description | Included | Optional Add-Ons |
|---|---|---|---|
| Antibody Engineering & Design | Antibody construct definition |  |  |
| DNA synthesis for small-scale transfection (≤1 L) | | |
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| DNA preparation for large-scale expression | | |
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| Pilot | Assessment of antibody expression levels | | |
| Small-scale antibody purification | | |
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| Transfection | Transient transfection (HEK293 or CHO; 100 mL–20 L) | | |
| Yield enhancement strategies (enhances expression consistency across production volumes) | | |
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| Supernatant concentration (supports efficient purification and material recovery) | | |
|
| Purification | Protein A or G purification | | |
| Buffer exchange to PBS (preservative- and stabilizer-free) | | |
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| Sterile filtration | | |
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| Purity and endotoxin assessment | | |
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| Vialing & QC | Sterile vialing | | |
| Internal quality assessment | | |
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| Certificate of Analysis (CoA) | | |
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| Analytical size exclusion chromatography (aggregate profile characterization) | | |
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| Murine pathogen screening | | |
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| Cold-pack shipping in environmentally friendly packaging | | |
Antibody Engineering Services FAQs
Antibody engineering services involve modifying antibody format, sequence, or expression characteristics to align with specific research needs. These services support format adaptation, expression optimization, and purification without entering antibody discovery or target identification.
Bio X Cell supports sequence-defined antibody engineering, including recombinant antibody formats, bispecific antibodies, Fab fragments, Fc modifications, and expression optimization using established recombinant systems.
Yes. Bio X Cell’s antibody engineering services are designed to support translational research workflows, from early mechanistic studies through IND-enabling programs, using in vivo–ready, ultra-pure, low-endotoxin formulations.
No. Bio X Cell does not perform antibody discovery, target identification, antigen design, immunization, screening, or lead optimization. Engineering services begin with customer-provided sequences, plasmids, or defined starting materials.
Yes. Antibody engineering services begin with existing sequences, DNA, or plasmids and focus on adapting format, expression, or functionality for defined research applications.
Supported formats include full-length recombinant antibodies, bispecific antibodies, Fab fragments (recombinant engineered or catalog customization), and Fc-modified constructs aligned to study requirements.
Yes. Engineering services may include expression optimization using HEK or CHO systems to support yield, consistency, and downstream production needs.
Engineered antibodies are purified using defined processes and assessed through internal quality evaluations aligned with research-use-only applications.
Engineered antibodies can be produced at scales appropriate for preclinical and translational studies, with defined QC processes to support reproducibility and study continuity.
Bio X Cell combines established recombinant systems, in vivo antibody expertise, and scientist-to-scientist guidance to deliver engineered antibodies aligned to translational research needs, scale, and reproducibility expectations.
Yes. Services support customization beyond standard formats, including Fc modifications, format adaptation, and construct-specific engineering.
Projects begin with a technical discussion to align starting materials, format requirements, and study goals before production planning begins.
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Whether you need antibody customization or high-volume production, Bio X Cell is committed to advancing your therapeutic innovations.
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