RecombiMAb anti-mouse CD4

Catalog #CP127
Clone:
GK1.5-CP127
Reactivities:
Mouse
Isotype:
Mouse IgG2b
(switched from rat IgG2b)

$217.00 - $5,910.00

Choose an Option...
  • 100 mg - $5,910.00
  • 50 mg - $4,229.00
  • 25 mg - $2,942.00
  • 5 mg - $843.00
  • 1 mg - $217.00
  • Custom Amount (Quotes Only)
In stock
Only %1 left

Product Details

The GK1.5-CP127 monoclonal antibody is a chimeric version of the original GK1.5 antibody. The variable domain sequences are identical to the original GK1.5 but the constant region sequences have been switched from rat IgG2b to mouse IgG2b. The GK1.5-CP127 antibody contains no Fc mutations just as the original rat IgG2b antibody does not. The GK1.5-CP127 monoclonal antibody reacts with the mouse CD4. The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which in cooperation with the T cell receptor (TCR) interacts with class II MHC molecules displayed by antigen presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.

Specifications

Isotype Mouse IgG2b, κ
Recommended Isotype Control(s) InVivoPlus mouse IgG2b isotype control, unknown specificity
Recommended Dilution Buffer InVivoPure pH 6.5 Dilution Buffer
Immunogen Mouse CTL clone V4
Reported Applications in vivo CD4+ T cell depletion*
Flow cytometry*
Western blot*
*Reported for the original rat IgG2b GK1.5 antibody
Formulation PBS, pH 6.5
Contains no stabilizers or preservatives
Endotoxin <1EU/mg (<0.001EU/μg)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by DLS
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from CHO cell supernatant in an animal free facility
Purification Protein G
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

Additional Formats

See the references for the original rat IgG2b GK1.5 antibody (https://bioxcell.com/catalogsearch/result/?q=BP0003-1).