Catalog #CP146

RecombiMAb anti-mouse CTLA-4 (CD152)

Clone 9H10-CP146
Reactivities Mouse
Product Citations 1
Isotype Mouse IgG1, κ

$235.00 - $6,391.00

$235.00 - $6.00

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  • 100 mg - $6,391.00
  • 50 mg - $4,574.00
  • 25 mg - $3,182.00
  • 5 mg - $911.00
  • 1 mg - $235.00
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Product Description

The 9H10-CP146 monoclonal antibody is a chimeric version of the original 9H10 antibody. The variable domain sequences are identical to the original 9H10 but the constant region sequences have been switched from Syrian hamster IgG to mouse IgG1. 9H10-CP146 reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28 family of the Ig superfamily. CTLA-4 is expressed on activated T and B lymphocytes. CTLA-4 is structurally similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to the B7 family members B7-1 (CD80) and B7-2 (CD86). Upon ligand binding, CTLA-4 negatively regulates cell-mediated immune responses. CTLA-4 plays roles in induction and/or maintenance of immunological tolerance, thymocyte development, and regulation of protective immunity. The critical role of CTLA-4 in immune down-regulation has been demonstrated in CTLA-4 deficient mice, which succumb at 3-5 weeks of age due to the development of a lymphoproliferative disease. CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through immune checkpoint blockade. The 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.

Specifications

Isotype Mouse IgG1, κ
Recommended Isotype Control(s) InVivoPlus mouse IgG1 isotype control, unknown specificity
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen Mouse CTLA-4-human IgG1 fusion protein
Reported Applications in vivo CTLA-4 neutralization*
in vitro CTLA-4 neutralization*
Western blot
*Reported for the original Syrian hamster IgG 9H10 antibody
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin ≤0.5EU/mg (≤0.0005EU/μg)
Determined by LAL gel clotting assay
Purity ≥95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from CHO cell supernatant in an animal-free facility
Purification Protein A
RRID AB_2927521
Molecular Weight 150 kDa
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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Additional Formats

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    InVivoPlus anti-mouse CTLA-4 (CD152) Read more