RecombiMAb anti-mouse/human CD11b

Catalog #CP051
Clone:
M1/70-CP051
Reactivities:
Mouse, Human

$541.00 - $7,325.00

$541.00 - $7,325.00

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  • 25 mg - $7,325.00
  • 5 mg - $2,097.00
  • 1 mg - $541.00
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In stock
Only %1 left
Isotype:
Mouse IgG2a
(switched from rat IgG2b)

Product Details

The M1/70-CP051 monoclonal antibody is a chimeric version of the original M1/70 antibody. The variable domain sequences are identical to the original M1/70 but the constant region sequences have been switched from rat IgG2b to mouse IgG2a. The M1/70-CP051 monoclonal antibody reacts with mouse and human CD11b, a 170 kDa membrane glycoprotein also known as integrin alpha M (ITGAM). CD11b belongs to the integrin alpha family and is primarily expressed on granulocytes and monocytes/macrophages but also expressed on dendritic cells, NK cells, and subsets of T and B cells. CD11b and CD18 combine to form Mac-1. Mac-1 functions as a complement receptor as well as a receptor for fibrinogen, factor X, and ICAM1.

Specifications

Isotype Mouse IgG2a, Īŗ
Recommended Isotype Control(s) InVivoPlus mouse IgG2a isotype control, unknown specificity
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen B10 mouse spleen cells enriched for T cells
Reported Applications in vivo CD11b neutralization*
ILC2 cell purification*
Flow cytometry*
*Reported for the original rat IgG2b M1/70 antibody
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <1EU/mg (<0.001EU/Ī¼g)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by SEC
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 Āµm filtration
Production Purified from HEK293 cell supernatant in an animal-free facility
Purification Protein G
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theilerā€™s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze.

See the references for the original rat IgG2b M1/70 antibody (https://bioxcell.com/be0007).