Programmable Transcriptome Engineering in T cell Therapy
Summary:
In this presentation, Dr. Stanley Qi presents cutting-edge CRISPR-based technologies that enable precise, non-DNA-editing control of gene expression. He shares how these tools uncover enhancer interactions driving cancer and how theyāre used to engineer more effective, long-lasting CAR T cells.
Topics to be covered:
- Synergistic enhancer interactions and their role in oncogene regulation and cancer relapse prediction
- Multiplexed RNA targeting in T cells using the MEGA CRISPR-Cas13 platform
- Development of non-DNA-editing CRISPR tools for safer gene and cell therapy applications
Speakers:
Lei (Stanley) Qi, PhD
Associate Professor, BioengineeringĀ
Stanford University