InVivoSIM anti-human IL-4Rα (CD124) (Dupilumab Biosimilar)

Catalog #SIM0023

$224.00 - $7,752.00

Choose an Option...
  • 100 mg - $7,752.00
  • 50 mg - $4,356.00
  • 25 mg - $3,030.00
  • 5 mg - $868.00
  • 1 mg - $224.00
  • Custom Amount (Quotes Only)
In stock
Only %1 left

Product Details

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Dupilumab making it ideal for research use. This Dupilumab biosimilar reacts with human IL-4Rα. IL-4Rα also known as CD124, associates with either the common γ-chain (CD132) to form type 1 IL-4R which only binds IL-4 or with IL-13Rα1 to form type II IL-4R which can bind IL-4 or IL-13. IL-4Rα is expressed on various cell types, including T helper type 2 (Th2) cells, mast cells, basophils, eosinophils, macrophages, dendritic cells, and endothelial cells. The expression of IL-4Rα on these different cell types allows for a variety of cellular responses to IL-4 and IL-13, including regulation of immune cell differentiation, activation, proliferation, and survival. Additionally, IL-4 and IL-13 signaling through IL-4Rα can promote tissue repair and remodeling, as well as contribute to the pathogenesis of various allergic and inflammatory diseases. Dupilumab binds IL-4Rα and inhibits signaling of both IL-4 and IL-13. It has shown efficacy across multiple diseases with underlying type 2 signatures and is used for treatment of asthma, atopic dermatitis, and chronic sinusitis with nasal polyposis.


Isotype Human IgG4, κ
Recommended Isotype Control(s) RecombiMAb human IgG4 (S228P) isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen Human IL-4Rα
Reported Applications Functional assays
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <1EU/mg (<0.001EU/μg)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by SEC
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant in an animal-free facility
Purification Protein A
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.