Catalog #SIM0045
InVivoSIM anti-human CD326 (EpCAM) (Edrecolomab Biosimilar)
Clone
Edrecolomab
Reactivities
Human
Isotype
Mouse IgG2a, κ
Product Description
This biosimilar antibody uses the same variable regions as the therapeutic antibody Edrecolomab, making it ideal for research use. Edrecolomab is a murine monoclonal antibody which reacts with tumor-associated epithelial cell adhesion molecule (EpCAM), also known as CD326 and 17-1A. EpCAM is a 40-42 kDa cell-surface type 1 transmembrane glycoprotein expressed on most epithelial cells as well as a small subset of peripheral T cells, keratinocytes, Langerhans cells and thymic, lymph node, and splenic dendritic cells. EpCAM is also expressed by various carcinomas, including those of the colon and breast. CD326 mediates cell-cell adhesion and may function as a growth factor receptor. Upon binding to EpCAM, Edrecolomab recruits the body's immune effector cells, which may exhibit antitumor cytotoxicity.
Specifications
| Isotype | Mouse IgG2a, κ |
|---|---|
| Recommended Isotype Control(s) | InVivoPlus mouse IgG2a isotype control, unknown specificity |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Immunogen | Human CD326 |
| Reported Applications |
Functional assays ELISA Flow cytometry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |