InVivoMAb anti-mouse DKK3

Catalog #BE0385
Clone:
DKK3-4.22
Reactivities:
Mouse

$159.00 - $4,155.00

Choose an Option...
  • 100 mg - $4,155.00
  • 50 mg - $2,936.00
  • 25 mg - $1,950.00
  • 5 mg - $583.00
  • 1 mg - $159.00
  • Custom Amount (Quotes Only)
In stock
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Product Details

The DKK3-4.22 monoclonal antibody reacts with mouse Dickkopf-3 (DKK3), a secreted glycoprotein and member of the Dickkopf family of molecules. DKK3 is expressed by multiple cell types, including neurons, endothelial cells, keratinocytes, and zona glomerulosa cells of the adrenal cortex. DKK3 is a multifunctional protein involved in various cellular processes, including embryonic development, cell differentiation, proliferation, and apoptosis, via the Wnt pathway. DKK-3 has been shown to potentiate Wnt signaling through interactions with the high-affinity, transmembrane co-receptors Kremen-1 and Kremen-2. DKK3 has been implicated in the pathogenesis of a variety of diseases, including cancer, chronic heart failure, and kidney disease. The expression of DKK3 is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene.

Specifications

Isotype Mouse IgG1, κ
Recommended Isotype Control(s) InVivoMAb mouse IgG1 isotype control, unknown specificity
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen Mouse DKK3-IgG2b fusion protein
Reported Applications in vivo DKK3 blocking
in vitro DKK3 blocking
Western blot
Flow cytometry
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <2EU/mg (<0.002EU/μg)
Determined by LAL gel clotting assay
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from tissue culture supernatant in an animal free facility
Purification Protein G
Molecular Weight 150 kDa
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.