InVivoMAb anti-human CEACAM5

Catalog #BE0401
Clone:
4H11-8

$164.00 - $4,280.00

Choose an Option...
  • 100 mg - $4,280.00
  • 50 mg - $3,024.00
  • 25 mg - $2,009.00
  • 5 mg - $600.00
  • 1 mg - $164.00
  • Custom Amount (Quotes Only)
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Product Details

The 4H11-8 monoclonal antibody reacts with human CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5). CEACAM5 is a cell surface protein that was discovered as a founding member of the carcinoembryonic antigen (CEA) family of proteins, and it is often called CEA or CD66e. CEACAM5 is expressed in the digestive system during the fetal or early embryonic stages and in neoplastic tissues. CEACAM5 acts as a cell adhesion molecule, and it mediates inter-cellular contact through both homophilic (CEACAM5 to CEACAM5) and heterophilic (CEACAM5 to CEACAM1 or CEACAM6) interactions. CEACAM5 inhibits anoikis, a type of apoptosis that is induced upon cell detachment from the ECM, and through this mechanism, CEACAM5 facilitates tumorigenesis and metastasis. CEACAM5 has a very low expression in normal adult tissues, and its expression gets upregulated in a variety of human epithelial malignancies such as breast cancer, colon cancer, lung cancer, neuro-endocrine prostate cancer (NEPC), and pancreatic cancers. CEACAM5 overexpression is directly linked to the processes of differentiation, invasion, and metastasis in various tumors. In cancer immunotherapy research, CEACAM5-targeted vaccines, bispecific T cell engagers (BiTEs), CAR T cell therapies, and antibody-drug conjugates are routinely tested in various experimental models.

Specifications

Isotype Mouse IgG1, κ
Recommended Isotype Control(s) InVivoMAb mouse IgG1 isotype control, unknown specificity
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <2EU/mg (<0.002EU/μg)
Determined by LAL gel clotting assay
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant in an animal-free facility
Purification Protein G
Molecular Weight 150 kDa
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.