Does TL1A-DR3 signaling play a role in your research?
InVivoMAb anti-mouse TL1A (TNFSF15)
The 5G4.6 monoclonal antibody reacts with the TNF family member TL1A, also known as TNFSF15. TL1A is expressed on activated T cells, dendritic cells, monocytes, and endothelial cells. TL1A expression has been shown to be induced by pro-inflammatory stimuli such as TNFĪ± and IL-1Ī±. In contrast to the TNFĪ± receptors, which are expressed on essentially all cells, the receptor for TL1A, DR3 (TNFRSF25), is primarily expressed on T cells, NK cells, and NKT cells, thereby limiting the effects of TL1A. TL1A-DR3 interactions are thought to promote effector T cell proliferation at the site of inflammation and in draining lymph nodes. Blockade of TL1A-DR3 interactions strikingly reduces pathology in several animal models in which autoreactive T cells play a role. TL1A has been linked to inflammatory bowel disease. The 5G4.2 antibody has been shown to block TL1A binding to DR3 and reduce disease severity in mouse models of colitis.
This Antibody Is Useful For:
- ā¢Ā in vivo TL1A neutralization
- ā¢Ā Flow cytometry
As always Bio X Cell antibodies are specifically formulated forĀ in vivoĀ use and feature:
- ā¢Ā 95% purity
- ā¢Ā Ultra-low endotoxin levels
- ā¢Ā Preservative, stabilizer, and carrier protein-free
Read how other researchers have used the anti-TL1A antibody.
Recommended Control and Buffer
InVivoMAb polyclonal Armenian hamster IgG
The polyclonal Armenian hamster IgG is purified from Armenian hamster serum. It is ideal for use as a non-reactive control IgG for Armenian hamster antibodies in mostĀ in vivoĀ andĀ in vitroĀ applications.
InVivoPure pH 7.0 Dilution Buffer
InVivoPureā¢Ā dilution buffers are specifically formulated and tested to satisfy the stringent requirements forĀ in vivoĀ applications. They are extremely low in endotoxin, have been screened for murine pathogens, tested in animal models for toxicity and are formulated with respect to buffer composition and pH to satisfy the requirements of Bio X Cellās antibodies.