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    MAb anti-human/monkey MDR-1 (CD243) (CloneĀ UIC2)

    Nov 03, 2020

      InVivoMAb anti-human/monkey MDR-1 (CD243) (Clone UIC2) The UIC2 monoclonal antibody reacts with an extracellular epitope of human and monkey (African Green) multidrug resistance protein 1 (MDR-1) also known as CD243, P-glycoprotein, and ABCB1. MDR-1 is a 170-180 kDa transmembrane glycoprotein that is expressed by epithelial and endothelial cells, and at low levels by T cells, B cells, NK cells, and hematopoietic stem cells. It is thought to be expressed at high levels by multidrug resistant (MDR) tumor cells. MDR-1 is as an ATP-dependent efflux pump for a large variety of molecules and drugs. This efflux activity has been suggested to lead to resistance to chemotherapy drugs. The UIC2 antibody has been reported to inhibit the efflux of MDR-1 substrates from MDR cells and increase the cytotoxicity of certain drugs in xenogeneic murine tumor models. The UIC2 antibody does not cross-react with mouse MDR-1.   References for InVivoMAb anti-human/monkey MDR-1 (CD243)   This antibody is useful for: in vivo MDR-1 blocking/depletion in xenogeneic murine tumor models in vitro MDR-1 blocking Immunohistochemistry (paraffin)   Bio X Cell antibodies are specifically formulated for in vivo use and feature: 95% purity Ultra-low endotoxin levels Preservative, stabilizer, and carrier protein-free   Recommended isotype control and dilution buffer: InVivoMAb mouse IgG2a isotype control, unknown specificity   The C1.18.4 monoclonal antibody is ideal for use as a non-reactive isotype-matched control for mouse IgG2a antibodies in most in vivo and in vitro applications. Shop Recommended Control     InVivoPure pH 7.0 Dilution Buffer Ā  InVivoPureā„¢Ā dilution buffers are specifically formulated and tested to satisfy the stringent requirements forĀ in vivoĀ applications. They are extremely low in endotoxin, have been screened for murine pathogens, tested in animal models for toxicity and are formulated with respect to buffer composition and pH to satisfy the requirements of Bio X Cell's antibodies. Shop Recommended Buffer

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