InVivoMAb anti-human CEACAM5
Catalog #BE0401
Clone:
4H11-8
Product Details
The 4H11-8 monoclonal antibody reacts with human CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5). CEACAM5 is a cell surface protein that was discovered as a founding member of the carcinoembryonic antigen (CEA) family of proteins, and it is often called CEA or CD66e. CEACAM5 is expressed in the digestive system during the fetal or early embryonic stages and in neoplastic tissues. CEACAM5 acts as a cell adhesion molecule, and it mediates inter-cellular contact through both homophilic (CEACAM5 to CEACAM5) and heterophilic (CEACAM5 to CEACAM1 or CEACAM6) interactions. CEACAM5 inhibits anoikis, a type of apoptosis that is induced upon cell detachment from the ECM, and through this mechanism, CEACAM5 facilitates tumorigenesis and metastasis. CEACAM5 has a very low expression in normal adult tissues, and its expression gets upregulated in a variety of human epithelial malignancies such as breast cancer, colon cancer, lung cancer, neuro-endocrine prostate cancer (NEPC), and pancreatic cancers. CEACAM5 overexpression is directly linked to the processes of differentiation, invasion, and metastasis in various tumors. In cancer immunotherapy research, CEACAM5-targeted vaccines, bispecific T cell engagers (BiTEs), CAR T cell therapies, and antibody-drug conjugates are routinely tested in various experimental models.Specifications
| Isotype | Mouse IgG1, Īŗ |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb mouse IgG1 isotype control, unknown specificity |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
<2EU/mg (<0.002EU/Ī¼g) Determined by LAL gel clotting assay |
| Purity |
>95% Determined by SDS-PAGE |
| Sterility | 0.2 Āµm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein G |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze. |
Recommended Products
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Recommended Isotype Control(s)
InVivoMAb mouse IgG1 isotype control, unknown specificity
-
Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer