InVivoSIM anti-human nectin-4 (Enfortumab Biosimilar)

Catalog #SIM0031
Clone:
Enfortumab
Reactivities:
Human

$217.00 - $7,526.00

Choose an Option...
  • 100 mg - $7,526.00
  • 50 mg - $4,229.00
  • 25 mg - $2,942.00
  • 5 mg - $843.00
  • 1 mg - $217.00
  • Custom Amount (Quotes Only)
In stock
Only %1 left

Product Details

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Enfortumab making it ideal for research use. This Enfortumab biosimilar reacts human nectin-4, also known as poliovirus receptor-related protein 4 (PVRL4). Nectin-4 belongs to the nectin family of cell adhesion molecules and plays a vital role in cell-cell adhesion. Nectin-4 is primarily expressed by epithelial cells, including those of the urinary bladder, lung, and breast tissue. It is involved in various biological processes such as tissue integrity maintenance, epithelial polarization, and immune response regulation. In recent years, nectin-4 has gained considerable attention in the context of cancer therapy, with the development of enfortumab vedotin, an antibody-drug conjugate that targets nectin-4, demonstrating promising results in the treatment of certain types of advanced urothelial cancers. This Enfortumab biosimilar antibody is only the antibody portion of Enfortumab vedotin and does not contain the drug conjugate.

Specifications

Isotype Human IgG1, κ
Recommended Isotype Control(s) RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen Human nectin-4
Reported Applications Functional assays
ELISA
Western blot
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <1EU/mg (<0.001EU/μg)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by SEC
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant
Purification Protein A
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.