Catalog #SIM0031
InVivoSIM anti-human nectin-4 (Enfortumab Biosimilar)
Clone
Enfortumab
Reactivities
Human
Isotype
Human IgG1, κ
Product Description
This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Enfortumab making it ideal for research use. This Enfortumab biosimilar reacts human nectin-4, also known as poliovirus receptor-related protein 4 (PVRL4). Nectin-4 belongs to the nectin family of cell adhesion molecules and plays a vital role in cell-cell adhesion. Nectin-4 is primarily expressed by epithelial cells, including those of the urinary bladder, lung, and breast tissue. It is involved in various biological processes such as tissue integrity maintenance, epithelial polarization, and immune response regulation. In recent years, nectin-4 has gained considerable attention in the context of cancer therapy, with the development of enfortumab vedotin, an antibody-drug conjugate that targets nectin-4, demonstrating promising results in the treatment of certain types of advanced urothelial cancers. This Enfortumab biosimilar antibody is only the antibody portion of Enfortumab vedotin and does not contain the drug conjugate.
Specifications
| Isotype | Human IgG1, κ |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Human nectin-4 |
| Reported Applications |
Functional assays ELISA Western blot |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |