InVivoSIM anti-human EGFR x MET (Amivantamab Biosimilar)
Catalog #SIM0081
Clone:
Amivantamab
Reactivities:
Human
Product Details
This biosimilar antibody uses the same variable regions as the therapeutic antibody Amivantamab, making it ideal for research use. Amivantamab is a fully human IgG1 bispecific monoclonal antibody that simultaneously targets the epidermal growth factor receptor (EGFR) and cāMet (MET). By binding to these receptors, it blocks ligand binding and promotes receptor internalization and degradation. Clinically, Amivantamab is approved for the treatment of adults with nonāsmall-cell lung cancer (NSCLC) bearing EGFR exon 20 insertion mutations, especially following disease progression after platinum-based chemotherapy. This Amivantamab biosimilar is intended only for research use, and is well suited for studying mechanisms of receptor blockade, receptor downmodulation, and immune effector activation in EGFR- and MET-driven tumor models.Specifications
| Isotype | Human IgG1, Īŗ |
|---|---|
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Reported Applications |
in vivo functional assays in vitro functional assays |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
<0.5EU/mg (<0.0005EU/Ī¼g) Determined by LAL gel clotting assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
>95% Determined by SDS-PAGE |
| Sterility | 0.2 Āµm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theilerās Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze. |
Recommended Products
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer