Catalog #SIM0035

InVivoSIM anti-human CD25 (IL-2Rα) (Daclizumab Biosimilar)

Clone Daclizumab
Reactivities Human
Isotype Human IgG1, κ

$235.00 - $8,140.00

$235.00 - $8.00

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  • 100 mg - $8,140.00
  • 50 mg - $4,574.00
  • 25 mg - $3,182.00
  • 5 mg - $911.00
  • 1 mg - $235.00
  • Custom Amount (Quotes Only)
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Product Description

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Daclizumab making it ideal for research use. The Daclizumab biosimilar antibody reacts with the Tac epitope on the α-subunit of human IL-2Rα also known as CD25, Ly-43, p55, or Tac. IL-2Rα is the 55 kDa ligand-binding subunit of the interleukin 2 receptor alpha chain. IL-2Rα is expressed on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Alone, the IL-2Rα binds IL-2 with relatively low affinity however, when IL-2Rα associates with IL-2Rβ (CD122) and the common gamma chain (CD132) the complex binds IL-2 with high affinity. Daclizumab functions by blocking the IL-2 binding site on the low- and high-affinity IL-2R without depleting T cells by antibody-dependent cellular cytotoxicity, complement mediated lysis or apoptosis, or activating the receptor and signaling pathways. This blockade results in the inhibition of several IL-2 dependent T-cell functions, including antigen- and mitogen-induced proliferation, cytokine secretion by activated Th1 and Th2 lymphocytes, and interference with CD28-dependent CD40 ligand expression.

Specifications

Isotype Human IgG1, κ
Recommended Isotype Control(s) RecombiMAb human IgG1 (D265A) isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Mutations E356D/M358L
Immunogen Human CD25
Reported Applications Functional assays
Western blot
Flow cytometry
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin ≤0.5EU/mg (≤0.0005EU/μg)
Determined by LAL gel clotting assay
Purity ≥95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant in an animal-free facility
Purification Protein A
Molecular Weight 150 kDa
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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