Murine Pathogen Testing

Our murine pathogen testing utilizes ultra-sensitive qPCR to screen for a multitude of murine pathogens. With two panels to choose from, our service ensures that the antibodies you are using for in vivo research will meet the requirements of your institution’s animal care committee.

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Murine Pathogen Screening

Viruses can be transmitted through biological materials, which may jeopardize in vivo experimental protocols and cause infections and other health problems in animals. This is a concern to many researchers and managers of animal facilities. Our InVivoPlus antibodies are carefully screened for murine pathogens, and we offer this as an optional service for InVivoMAb antibodies and antibodies that we custom-produce from your hybridoma cells. This ensures that the antibodies are free of murine pathogens and that you have the documentation to satisfy the requirements of your institution’s animal facility and IACUC committee.

Traditional mouse antigen production (MAP) testing requires the use of live animals to detect viruses in biological samples. Bio X Cell employs the latest technology to detect murine pathogens, an ultra-sensitive qPCR technique which boasts lower costs, rapid turnaround times, and eliminates the need for live animals.

We recommend murine pathogen testing for any antibody used in an in vivo application. Bio X Cell offers two different testing panels to choose from. Our MAP1 panel screens for six different essential mouse viruses and our MAP2 panel screens for a comprehensive list of 19 different pathogens. Review the table below to select the panel that best meets the requirements of the facility that you are using for your in vivo research.

Key Features

Advanced Technique - Bio X Cell’s qPCR method features sensitivity, specificity, speed, and enables effortless addition of positive and negative controls, rivaling other testing methods. If your internal testing facility uses more traditional screening approaches, try our method for early detection that you can trust.

Meets Varying Standards - With two panels to choose from, Bio X Cell can accommodate the demands of any animal care facility or CRO. Our MAP1 panel meets the minimum requirements of IACUC committees, whereas our MAP2 panel exceeds the most demanding requirements.

Reduces Animals - At Bio X Cell we embrace the 3R’s of animal welfare, Reduction, Refinement, and Replacement. Our qPCR method is a replacement for traditional pathogen testing involving live mice. As a vendor of a biologic that is used for in vivo research, we believe that it is our responsibility to advocate for pathogen testing to lessen re-work and reduce the number of animals used.

Animal Free Facility - Did you know that Bio X Cell is an animal-free facility? Our antibody production process is ultra-clean and there is no risk of contamination of murine viruses or bacteria from animal dander. You can trust the purity and cleanliness of our antibodies for your important in vivo and in vitro studies.

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A Comparison of Bio X Cell’s Pathogen Testing Panels:

Mouse parvovirus (MPV)
Mouse minute virus (MVM)
mouse hepatitis virus (MHV)
Theiler's murine encephalomyelitis (TMEV)
sendai virus
pneumonia virus of mice (PVM)
Mouse Norovirus (MNV)
Reovirus screen (REO)
Lymphocytic choriomeningitis virus (LCM)
Lactate dehydrogenase-elevating virus (LDEV)
mouse rotavirus (EDIM)
Ectromelia/mousepox virus
Hantavirus
Polyoma virus
mouse adenovirus 1 (MAD/V1)
mouse cytomegalovirus (MCMV)
K Virus
mouse adenovirus 2 (MAD/V2)
mycoplasma

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Other Services

Mycoplasma Testing

Bio X Cell also offers mycoplasma testing of your hybridoma cell line to eliminate bacterial contamination at the earliest possible point in the antibody production process to ensure delivery of the highest quality, cleanest product.