InVivoSIM GLP-1 Receptor Agonist (Dulaglutide Biosimilar)
Catalog #SIM0077
Product Details
This research-grade Dulaglutide biosimilar is a recombinant glucagon-like peptide-1 (GLP-1) analog useful for studies on metabolic disorders, especially type 2 diabetes mellitus (T2DM) and related conditions. Dulaglutide consists of amino acids 7ā37 of GLP-1 covalently linked to the Fc fragment of human IgG4, wherein the Fc fragment protects the GLP-1 moiety from enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), thereby extending its stability. As an incretin mimetic, dulaglutide acts as an agonist of the GLP-1 receptor (GLP-1R), a G proteinācoupled receptor that plays a central role in regulating glucose homeostasis, insulin secretion, gastric emptying, and satiety. Binding of GLP-1 or its analogs to GLP-1R activates adenylyl cyclase, increasing intracellular cAMP levels and triggering insulin release in a glucose-dependent manner. Through this mechanism, dulaglutide enhances insulin secretion when glucose levels are elevated, reduces glucagon secretion, and delays gastric emptying, thereby lowering postprandial glucose levels. Extensive in vitro and in vivo studies have shown dulaglutide to stimulate glucose-dependent insulin secretion, suppress obesity, improve cardiovascular risk factors, and offer protection against T2DM-associated conditions including sarcopenia, neuroinflammation, and kidney disease. Chronic treatment studies in animal models, including rats, transgenic mice, and monkeys, have been reported, with many mouse studies documenting the use of dulaglutide at 0.6 mg/kg for multi-week experiments.Specifications
| Isotype | Human IgG4, Īŗ |
|---|---|
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Reported Applications |
in vitro functional assays in vivo functional assays For more information, please contact technicalservice@bioxcell.com |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Aggregation |
<5% Determined by SEC |
| Purity |
>95% Determined by SDS-PAGE |
| Sterility | 0.2 Āµm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 59.7 |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theilerās Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze. |
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer