InVivoSIM GIPR/GLP‑1R Dual Agonist (Tirzepatide Biosimilar)
Catalog #SIM0083
Product Details
This research-grade Tirzepatide biosimilar is a long-acting dual agonist of the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP‑1R). Tirzepatide is a synthetic 39-amino acid peptide designed to mimic the native GIP hormone but chemically modified with a C20 fatty diacid moiety to enhance half-life and stability. By selectively activating both GIP and GLP‑1 receptors, key incretin receptors expressed on pancreatic beta cells and hypothalamic neurons, tirzepatide stimulates insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite, resulting in lower blood glucose and body weight. In experimental research, tirzepatide has demonstrated potent glucose-lowering activity, enhanced insulin sensitivity, and appetite regulation. It has been used in models of type 2 diabetes (T2D) and is also being studied for its effects on cardiovascular health, chronic kidney disease (CKD), Alzheimer’s disease, metabolic dysfunction-associated nonalcoholic steatohepatitis disease (MASLD), and obstructive sleep apnea (OSA). This tirzepatide biosimilar is ideal for investigating GIPR/GLP‑1R signaling, metabolic hormone synergy, and incretin biology in disease-relevant models.Specifications
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
|---|---|
| Reported Applications |
in vitro functional assays in vivo functional assays ex vivo functional assays |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
<0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
>95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Molecular Weight | 4.81 |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer