InVivoSIM anti-human IL-23 (p19) (Guselkumab Biosimilar)

Catalog #SIM0025
Clone:
Guselkumab
Reactivities:
Human

$217.00 - $7,526.00

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  • 100 mg - $7,526.00
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Product Details

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Guselkumab making it ideal for research use. This Guselkumab biosimilar reacts with the p19 subunit of human IL-23. IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 has been shown to enhance IFNγ production by memory T cells. Additionally, IL-23 induces the proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. IL-23 (but not IL-12) can also activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17. IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections. Guselkumab targets the IL-23 p19 subunit preventing it from binding to cell receptors that would otherwise be activated by its presence. Guselkumab is used to treat moderate to severe plaque psoriasis, and psoriatic arthritis.

Specifications

Isotype Human IgG1, λ
Recommended Isotype Control(s) RecombiMAb human IgG1 isotype control, anti-respiratory syncytial virus
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen Human IL-23 p19
Reported Applications IL-23p19 neutralization
Functional assays
ELISA
Western blot
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <1EU/mg (<0.001EU/μg)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by SEC
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from tissue culture supernatant in an animal free facility
Purification Protein A
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.