InVivoSIM anti-human IL-1β (Gevokizumab Biosimilar)

Catalog #SIM0049
Clone:
Gevokizumab
Reactivities:
Human, Monkey

$224.00 - $7,752.00

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  • 100 mg - $7,752.00
  • 50 mg - $4,356.00
  • 25 mg - $3,030.00
  • 5 mg - $868.00
  • 1 mg - $224.00
  • Custom Amount (Quotes Only)
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Product Details

This biosimilar antibody uses the same variable regions as the therapeutic antibody Gevokizumab, making it ideal for research use. Gevokizumab is a fully humanized monoclonal antibody that reacts with human IL-1β, a potent pro-inflammatory cytokine produced primarily by monocytes. Inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1 β, and after inflammasome assembly-mediated CASP1 activation, pro-IL1 is processed to generate active cytokine for secretion. IL-1β is an important mediator of the inflammatory response and is involved in a variety of cellular activities, including cell proliferation, differentiation, apoptosis, and T and B lymphocyte activation, neutrophil influx and activation, cytokine production, antibody production, fibroblast proliferation, and the synthesis of collagen as well as prostaglandins. IL-1β promotes Th17 differentiation of T-cells and also shows synergism with IL-12 to induce IFN-γ synthesis from Th1 cells. The Gevokizumab antibody binds a unique IL-1β epitope that is proximal to, but does not overlap with, the receptor/ligand interface, and this interaction reduces the binding of IL-1 to its receptor, i.e., IL-1 receptor type I (IL-1RI or CD121a). Gevokizumab neutralizes the human IL-1β by binding to it, and this antibody is used in preclinical research involving in vitro and in vivo experimental models of type 1 diabetes mellitus, inflammation, rheumatoid arthritis, cardiovascular biology, and cancer immunotherapy.

Specifications

Isotype Human IgG2, κ
Recommended Isotype Control(s) RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen Human IL-1β
Reported Applications in vivo neutralization of human IL1β
in vitro neutralization of human IL1β
ELISA
Western blot
Flow cytometry
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <0.5EU/mg (<0.0005EU/μg)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by SEC
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant in an animal-free facility
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.