Catalog #RP099
Recombinant human/mouse IGF-2 protein
Reactivities
Porcine, Mouse, Human, Rat, Bovine
Applications
Cellular proliferation, migration and survival
iPSC and primary cell differentiation to muscle
Osteogenic differentiation
iPSC and primary cell differentiation to muscle
Osteogenic differentiation
Product Description
Recombinant human/mouse IGF-2 protein (insulin-like growth factor 2) is a 67-amino-acid, 7.5 kDa single-chain polypeptide hormone of the insulin-like growth factor family, which also includes IGF-1 and insulin, with an insulin-like fold of three α-helices stabilized by three disulfide bonds between six conserved cysteine residues that are critical for its tertiary structure and biological activity. IGF-2 plays a crucial role in growth and development, particularly fetal growth, influencing organ size and body composition, and is used as a marker in prenatal diagnostics. It is implicated in colorectal, breast and prostate cancer, where it is studied as a biomarker and therapeutic target, and is investigated in metabolic disorders such as diabetes and obesity given its role in glucose metabolism. IGF-2 also has applications in tissue engineering and regenerative medicine, particularly wound healing and tissue repair, shows neuroprotective effects relevant to neurodegenerative disorders such as Alzheimer's disease, and its gene polymorphisms serve as markers for selective breeding to improve meat quality, making recombinant IGF-2 a versatile reagent for developmental biology, cancer, metabolic and regenerative research.
This protein is optimized for in vivo and functional applications: low-endotoxin, tag-free, and carrier-free, supporting reproducible performance in demanding preclinical and bioactivity studies.
A GMP-grade version of this protein is available for cell and gene therapy manufacturing. Contact us at customerservice@bioxcell.com for details.
Species reactivity: human. Species similarity: mouse - 91%, rat - 94%, bovine - 95%, porcine - 98%.
This protein is optimized for in vivo and functional applications: low-endotoxin, tag-free, and carrier-free, supporting reproducible performance in demanding preclinical and bioactivity studies.
A GMP-grade version of this protein is available for cell and gene therapy manufacturing. Contact us at customerservice@bioxcell.com for details.
Species reactivity: human. Species similarity: mouse - 91%, rat - 94%, bovine - 95%, porcine - 98%.
Specifications
| Reported Applications |
Cellular proliferation, migration and survival iPSC and primary cell differentiation to muscle Osteogenic differentiation |
|---|---|
| Formulation | Lyophilized, white powder |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | Sterile |
| Production | Microbial. Expressed in E. coli |
| Molecular Weight | 7.5 kDa |
| Storage | Store lyophilized protein between -20 °C and -80 °C until the date of expiry. Avoid freeze-thaw cycles |
| Mycoplasma | Negative |
| Bioactivity Assay | No significant difference between EC50 of reference and test lots |
| Reconstitution | Resuspend in sterile-filtered water at >50 µg/ml. Once reconstituted, store in single-use aliquots to avoid freeze-thaw cycles. Store reconstituted protein at -20 °C to -80 °C for a maximum of 12 months or until the expiry date if sooner. |
| Shelf Life | This product has a guaranteed shelf-life of one year from the date of customer receipt when stored as recommended. |