Catalog #RP089
Recombinant human IL-15 protein
Reactivities
Human
Applications
Development, survival, and function of T cells
Development and formation of NK cells
Development and formation of B cells
Differentiation of myeloid cells into dendritic cells
Hematopoietic stem cell research
Development and formation of NK cells
Development and formation of B cells
Differentiation of myeloid cells into dendritic cells
Hematopoietic stem cell research
Product Description
Recombinant human IL-15 protein (interleukin-15) is a pro-inflammatory cytokine expressed by a wide variety of tissues and cell types, including epithelial cells, fibroblasts, keratinocytes, nerve cells, monocytes, macrophages and dendritic cells. Although it lacks sequence homology with IL-2, IL-15 shares many of its biological properties by interacting with components of the IL-2 receptor, inducing JAK kinase activation and phosphorylation of the transcription activators STAT3, STAT5 and STAT6. IL-15 stimulates the proliferation and activation of multiple lymphocyte subsets, including NK, NKT, Th17, Treg and CD8+ memory T cells, and is essential for NK cell development. IL-15 plays a role in inflammatory disorders such as rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases, with IL-15 neutralization showing beneficial effects in models of psoriasis and diabetes, and it is implicated in both the development and treatment of cancers. In cell culture, recombinant IL-15 is used to develop NK cells from hematopoietic progenitor cells, to precondition CAR T cells and to support engineering of cells that express IL-15 in vivo, making it a key reagent for immunology and cell therapy research.
This protein is optimized for in vivo and functional applications: low-endotoxin, tag-free, and carrier-free, supporting reproducible performance in demanding preclinical and bioactivity studies.
A GMP-grade version of this protein is available for cell and gene therapy manufacturing. Contact us at customerservice@bioxcell.com for details.
Species reactivity: human. Species similarity: mouse - 73%, rat - 72%, bovine - 78%, porcine - 81%.
This protein is optimized for in vivo and functional applications: low-endotoxin, tag-free, and carrier-free, supporting reproducible performance in demanding preclinical and bioactivity studies.
A GMP-grade version of this protein is available for cell and gene therapy manufacturing. Contact us at customerservice@bioxcell.com for details.
Species reactivity: human. Species similarity: mouse - 73%, rat - 72%, bovine - 78%, porcine - 81%.
Specifications
| Reported Applications |
Development, survival, and function of T cells Development and formation of NK cells Development and formation of B cells Differentiation of myeloid cells into dendritic cells Hematopoietic stem cell research |
|---|---|
| Formulation | Lyophilized, white powder |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | Sterile |
| Production | Microbial. Expressed in E. coli |
| Molecular Weight | 12.9 kDa (monomer) |
| Storage | Store lyophilized protein between -20 °C and -80 °C until the date of expiry. Avoid freeze-thaw cycles |
| Mycoplasma | Negative |
| Bioactivity Assay | No significant difference between EC50 of reference and test lots |
| Reconstitution | Resuspend in 10 mM HCl (Reconstitution Buffer A) at >50 µg/ml. Once reconstituted, store in single-use aliquots to avoid freeze-thaw cycles. Store reconstituted protein at -20 °C to -80 °C for a maximum of 12 months or until the expiry date if sooner. |
| Shelf Life | This product has a guaranteed shelf-life of one year from the date of customer receipt when stored as recommended. |