Catalog #RP086
Recombinant human FGF-19 protein
Reactivities
Human
Applications
Metabolic disease research
Liver cell regeneration
Cancer research including gastrointestinal cancers
Directed osteogenic differentiation of mesenchymal stem cells
Liver cell regeneration
Cancer research including gastrointestinal cancers
Directed osteogenic differentiation of mesenchymal stem cells
Product Description
Recombinant human FGF-19 protein (fibroblast growth factor 19) is a 25 kDa member of the fibroblast growth factor family, produced primarily in the ileum in response to bile acids, that regulates bile acid homeostasis, glucose metabolism and lipid regulation. FGF-19 shares the core beta-trefoil fold of other FGFs, formed by anti-parallel beta-sheets, and binds FGFR4 together with the beta-Klotho co-receptor in target tissues such as the liver, an interaction that favors metabolic functions over the cell proliferation characteristic of other FGFs. Lacking the conventional heparin-binding domain, FGF-19 acts in an endocrine-like manner, circulating to act distally from its site of production. In obesity and type 2 diabetes, FGF-19 reduces hepatic glucose production and enhances insulin sensitivity, and its role in cholesterol metabolism makes it a candidate for non-alcoholic fatty liver disease (NAFLD) and primary bile acid disorders. Recombinant FGF-19 is used in studies of metabolic syndrome, liver disease and cancer, including efforts to improve liver function and reduce inflammation in cirrhosis and NAFLD, making it a key reagent for metabolic and liver disease research.
This protein is optimized for in vivo and functional applications: low-endotoxin, tag-free, and carrier-free, supporting reproducible performance in demanding preclinical and bioactivity studies.
A GMP-grade version of this protein is available for cell and gene therapy manufacturing. Contact us at customerservice@bioxcell.com for details.
Species reactivity: human. Species similarity: mouse - 51%, rat - 52%, bovine - 75%, porcine - 77%.
This protein is optimized for in vivo and functional applications: low-endotoxin, tag-free, and carrier-free, supporting reproducible performance in demanding preclinical and bioactivity studies.
A GMP-grade version of this protein is available for cell and gene therapy manufacturing. Contact us at customerservice@bioxcell.com for details.
Species reactivity: human. Species similarity: mouse - 51%, rat - 52%, bovine - 75%, porcine - 77%.
Specifications
| Reported Applications |
Metabolic disease research Liver cell regeneration Cancer research including gastrointestinal cancers Directed osteogenic differentiation of mesenchymal stem cells |
|---|---|
| Formulation | Lyophilized, white powder |
| Endotoxin |
≤0.5 EU/mg LAL assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | Sterile |
| Production | Microbial. Expressed in E. coli |
| Molecular Weight | 21.8 kDa (monomer) |
| Storage | Store lyophilized protein between -20 °C and -80 °C until the date of expiry. Avoid freeze-thaw cycles |
| Mycoplasma | Negative |
| Bioactivity Assay | No significant difference between EC50 of reference and test lots |
| Reconstitution | Resuspend in sterile-filtered water at >50 µg/ml. Once reconstituted, store in single-use aliquots to avoid freeze-thaw cycles. Store reconstituted protein at -20 °C to -80 °C for a maximum of 12 months or until the expiry date if sooner. |
| Shelf Life | This product has a guaranteed shelf-life of one year from the date of customer receipt when stored as recommended. |