$541.00 - $7,325.00

$541.00 - $7.00

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  • 25 mg - $7,325.00
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Product Description

16A11-CP075 monoclonal antibody is a recombinant, chimeric version of the original 16A11 antibody. The variable domain sequences are identical but the constant region has been switched from mouse IgG2b to mouse IgG2a. 16A11-CP075 also contains the Fc silencing mutation LALA-PG rendering it unable to bind to endogenous Fcγ receptors thus preventing effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). The highly controlled sequence and lack of genetic drift in recombinant antibodies provide more reliable and reproducible results over hybridoma derived antibodies. The 16A11 antibody reacts with NKG2A from C57BL/6 mice and does not react with BALB/c or 129 mouse strains. NKG2A, also known as CD159a is a type II transmembrane glycoprotein which belongs to the killer cell lectin-like receptor (KLR) family. NKG2A is expressed on NK cells, NKT cells, and activated CD8 T cells. NKG2A forms a disulfide-bonded heterodimer with CD94 that can bind to non-classical MHC class I antigen Qa-1 on target cells and inhibit NK cell activation.

Specifications

Isotype Mouse IgG2a LALA-PG
Recommended Isotype Control(s) RecombiMAb mouse IgG2a (LALA-PG) isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Mutations LALA-PG
Immunogen C57BL/6 mouse CD94/NKG2A transfected CHO cells
Reported Applications Flow Cytometry
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin ≤0.5EU/mg (≤0.0005EU/μg)
Determined by LAL gel clotting assay
Purity ≥95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from mammalian cell supernatant in an animal-free facility
Purification Protein G
Molecular Weight 150 kDa
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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Additional Formats

  1. Catalog #BE0339
    InVivoMAb anti-mouse NKG2AB6 Read more