Catalog #SIM0014
    InVivoSIM anti-human IL-6R (Tocilizumab Biosimilar)
                Clone
                Tocilizumab
            
	
             
                    
                Reactivities
                Human
            
	
             
        
             
        
             
                    
                Isotype
                Human IgG1
            
	
    Product Description
        This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Tocilizumab making it ideal for research use. This Tocilizumab biosimilar reacts with human IL-6 receptor also known as CD126. IL-6R is an 80 kDa type I cytokine receptor and a member of the immunoglobulin superfamily. IL-6R is expressed by activated T and B lymphocytes, monocytes, hepatocytes, and plasma cells. The IL-6 receptor α chain binds IL-6 but requires association with gp130 to initiate signal transduction. Upon IL-6 binding the IL-6R complex influences antigen-specific immune responses, inflammatory responses, neuronal development, and is a major mediator of the acute phase reaction. Tocilizumab binds to both soluble and membrane bound IL-6R and blocks the binding of IL-6 to IL-6R.        
Specifications
| Isotype | Human IgG1 | 
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme | 
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer | 
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. | 
| Immunogen | Human IL-6R | 
| Reported Applications | Functional assays ELISA | 
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives | 
| Endotoxin | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay | 
| Aggregation | <5% Determined by SEC | 
| Purity | ≥95% Determined by SDS-PAGE | 
| Sterility | 0.2 µm filtration | 
| Production | Purified from cell culture supernatant in an animal-free facility | 
| Purification | Protein A | 
| RRID | AB_2894735 | 
| Molecular Weight | 150 kDa | 
| Murine Pathogen Tests | Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative | 
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. | 
| Need a Custom Formulation? | See All Antibody Customization Options | 
