Catalog #SIMB0097
InVivoSIM bispecific anti-human PD-1 x CTLA-4 (Cadonilimab Biosimilar)
Clone
Cadonilimab
Reactivities
Human
Isotype
Human IgG1, κ
Product Description
This Cadonilimab biosimilar antibody uses the same variable regions as the therapeutic antibody Cadonilimab, making it ideal for research use. Cadonilimab is a tetravalent bispecific IgG1 antibody that simultaneously targets human PD-1 and CTLA-4, two inhibitory immune checkpoints that regulate T-cell activation, proliferation, and antitumor responses. By binding both PD-1 and CTLA-4, Cadonilimab enhances T-cell activation more efficiently than monospecific antibodies and promotes potent antitumor immunity within the tumor microenvironment. Importantly, Cadonilimab’s Fc region is engineered to minimize FcγR binding and reduce toxicity, particularly immune-related adverse events commonly associated with anti-CTLA-4 therapies, while preserving strong checkpoint-blocking activity. Clinically, Cadonilimab has demonstrated efficacy in multiple cancer types, including recurrent or metastatic cervical cancer, by enhancing T-cell infiltration, reducing regulatory T-cell–mediated suppression, and amplifying antitumor immune responses. This Cadonilimab biosimilar is well suited for studying dual checkpoint regulation, T-cell activation pathways, immune-oncology mechanisms, and the therapeutic potential of multivalent bispecific checkpoint inhibitors.
Specifications
| Isotype | Human IgG1, κ |
|---|---|
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | Ala substitutions at Fc positions 235, 236, and 238 |
| Reported Applications |
in vivo functional assays in vitro functional assays ELISA |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |