Catalog #SIMB0118
InVivoSIM bispecific anti-human IGF-1R x HER3 (Istiratumab Biosimilar)
Clone
Istiratumab
Reactivities
Human
Product Description
This Istiratumab biosimilar antibody uses the same variable regions as the therapeutic antibody Istiratumab, making it ideal for research use. Istiratumab is a bispecific monoclonal antibody that simultaneously targets human insulin-like growth factor 1 receptor (IGF-1R) and ERBB3 (HER3), two receptor tyrosine kinases involved in tumor cell proliferation, survival, and resistance signaling. IGF-1R and HER3 signaling pathways can cooperate to promote activation of downstream PI3K/AKT and MAPK pathways, contributing to tumor growth and therapeutic resistance in multiple solid tumors. By binding both IGF-1R and HER3, Istiratumab is designed to inhibit ligand-dependent receptor activation, disrupt compensatory signaling between these pathways, and suppress downstream pro-survival signaling. This dual-targeting approach provides a valuable model for studying receptor crosstalk and combination pathway inhibition in oncology. This Istiratumab biosimilar is well suited for investigating IGF-1R/HER3 signaling biology, tumor resistance mechanisms, receptor co-targeting strategies, and for benchmarking the therapeutic antibody’s mechanism of action in pre-clinical experimental systems.
Specifications
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
|---|---|
| Reported Applications |
In vivo functional assays in vitro functional assays ELISA |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| RRID | AB_3751737 |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |