Catalog #SIM0069
InVivoSIM bispecific anti-human CD3 x GPRC5D (Talquetamab Biosimilar)
Clone
Talquetamab
Reactivities
Human
Applications
Functional assays
Flow cytometry
ELISA
Immunohistochemistry
Flow cytometry
ELISA
Immunohistochemistry
Isotype
Human IgG4, κ
Product Description
This non‑therapeutic bispecific biosimilar antibody uses the same variable regions as the therapeutic bispecific Talquetamab, making it ideal for research use. Talquetamab is a humanized IgG4 bispecific T‑cell engager (BiTE) that targets GPRC5D, a receptor highly expressed on multiple myeloma cells, and CD3ε on T cells. It redirects T cells to form a cytotoxic synapse with GPRC5D-positive tumor cells, triggering perforin- and granzyme-mediated apoptosis of malignant plasma cells.
Specifications
| Isotype | Human IgG4, κ |
|---|---|
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | S228P/F234A/L235A |
| Reported Applications |
Functional assays Flow cytometry ELISA Immunohistochemistry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| RRID | AB_3720049 |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |