Catalog #SIMB0104
InVivoSIM bispecific anti-human CD3 x Claudin 18.2 (Gresonitamab Biosimilar)
Clone
Gresonitamab
Reactivities
Human
Product Description
This Gresonitamab biosimilar antibody uses the same variable regions as the therapeutic antibody Gresonitamab, making it ideal for research use. Gresonitamab is a bispecific antibody in a scFv–scFv format that simultaneously targets human CD3 on T cells and Claudin 18.2 (CLDN18.2), a tight junction protein selectively expressed on gastric and other gastrointestinal tumor cells. By binding CD3 and Claudin 18.2, Gresonitamab redirects T cells to Claudin 18.2–expressing tumor cells, promoting immune synapse formation, T-cell activation, cytokine release, and targeted cytotoxicity. This T-cell–engaging mechanism enables potent and selective killing of tumor cells independent of native antigen presentation. Claudin 18.2 is normally restricted to differentiated gastric mucosa but becomes exposed and overexpressed in malignant tissues, making it an attractive tumor-associated antigen. This Gresonitamab biosimilar is well suited for studying T-cell redirection, Claudin 18.2–targeted tumor killing, gastrointestinal tumor biology, and the mechanistic basis of CD3-engaging bispecific antibody therapeutics.
Specifications
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
|---|---|
| Reported Applications |
in vivo functional assays in vitro functional assays ELISA |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |