Catalog #SIMB0111
InVivoSIM bispecific anti-human BCMA x CD3 (Elranatamab Biosimilar)
Clone
Elranatamab
Reactivities
Human
Isotype
Human IgG2, κ
Product Description
This Elranatamab biosimilar antibody uses the same variable regions as the therapeutic antibody Elranatamab, making it ideal for research use. Elranatamab is a humanized bispecific antibody that simultaneously targets human CD3 on T cells and B-cell maturation antigen (BCMA; TNFRSF17) on malignant plasma cells. By binding CD3 and BCMA, Elranatamab redirects T cells to BCMA-expressing target cells, promoting immune synapse formation, T-cell activation, cytokine release, and targeted cytotoxicity against malignant plasma cells. This T-cell–engaging mechanism enables potent tumor cell killing independent of native antigen presentation and makes Elranatamab a valuable model for studying BCMA-directed immunotherapy. BCMA is highly expressed on plasma cells and multiple myeloma cells, with more limited expression on mature B-cell populations, making it an attractive therapeutic target in hematologic malignancies. This Elranatamab biosimilar is well suited for studying T-cell redirection, BCMA-targeted tumor killing, plasma cell biology, multiple myeloma immunotherapy, and the mechanistic basis of CD3-engaging bispecific antibody therapeutics.
Specifications
| Isotype | Human IgG2, κ |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Reported Applications |
in vivo functional assays in vitro functional assays ELISA |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| RRID | AB_3751732 |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |