Catalog #SIM0068
InVivoSIM anti-human sclerostin (SOST) (Romosozumab Biosimilar)
Clone
Romosozumab
Reactivities
Human
Isotype
Human IgG2, κ
Product Description
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Romosozumab, making it ideal for research use. Romosozumab is a humanized IgG2κ monoclonal antibody that targets sclerostin (SOST), a secreted glycoprotein produced by osteocytes. Sclerostin negatively regulates bone formation by binding LRP4/5/6 and inhibiting Wnt/β‑catenin signaling—a key pathway for osteoblast activity. By neutralizing sclerostin, Romosozumab promotes bone formation while simultaneously suppressing bone resorption. This Romosozumab biosimilar is intended for non-therapeutic research use and can support studies on osteoanabolic mechanisms, Wnt signaling, and sclerostin function in bone biology.
Specifications
| Isotype | Human IgG2, κ |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 6.0T Dilution Buffer |
| Immunogen | Human SOST |
| Reported Applications |
In vitro and ex vivo assays of sclerostin neutralization ELISA Western blot Flow cytometry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |