InVivoSIM anti-human sclerostin (SOST) (Romosozumab Biosimilar)

Catalog #SIM0068
Clone:
Romosozumab
Reactivities:
Human

$235.00 - $8,140.00

$235.00 - $8,140.00

Choose an Option...
  • 100 mg - $8,140.00
  • 50 mg - $4,574.00
  • 25 mg - $3,182.00
  • 5 mg - $911.00
  • 1 mg - $235.00
  • Custom Amount (Quotes Only)
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Product Details

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Romosozumab, making it ideal for research use. Romosozumab is a humanized IgG2Īŗ monoclonal antibody that targets sclerostin (SOST), a secreted glycoprotein produced by osteocytes. Sclerostin negatively regulates bone formation by binding LRP4/5/6 and inhibiting Wnt/β‑catenin signaling—a key pathway for osteoblast activity. By neutralizing sclerostin, Romosozumab promotes bone formation while simultaneously suppressing bone resorption. This Romosozumab biosimilar is intended for non-therapeutic research use and can support studies on osteoanabolic mechanisms, Wnt signaling, and sclerostin function in bone biology.

Specifications

Isotype Human IgG2, Īŗ
Recommended Isotype Control(s) RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer InVivoPure pH 6.0T Dilution Buffer
Immunogen Human SOST
Reported Applications In vitro and ex vivo assays of sclerostin neutralization
ELISA
Western blot
Flow cytometry
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <0.5EU/mg (<0.0005EU/μg)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by SEC
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant in an animal-free facility
Purification Protein A
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.