Catalog #SIM0078

InVivoSIM anti-human IL-31RA (Nemolizumab Biosimilar)

Clone Nemolizumab
Reactivities Human
Isotype Human IgG2, κ

$235.00 - $8,140.00

$235.00 - $8.00

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  • 100 mg - $8,140.00
  • 50 mg - $4,574.00
  • 25 mg - $3,182.00
  • 5 mg - $911.00
  • 1 mg - $235.00
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Product Description

This non‑therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Nemolizumab making it ideal for research use. Nemolizumab is a humanized IgG2 monoclonal antibody that specifically targets the interleukin-31 receptor alpha (IL-31RA). IL‑31RA is primarily expressed on keratinocytes, dorsal root ganglion (DRG) neurons, monocytes, macrophages, and dendritic cells, where it mediates the biological effects of IL‑31, a cytokine known for driving pruritus, inflammation, and epithelial barrier dysfunction. By binding to IL-31RA, it blocks the signaling of interleukin-31 (IL‑31)—a neuroimmune cytokine that drives itch (pruritus), skin inflammation, barrier dysfunction, and fibrosis—thereby interrupting the pathogenic itch–scratch cycle seen in skin disorders like atopic dermatitis (AD) and prurigo nodularis (PN) . Nemolizumab has been shown to provide rapid and sustained relief of pruritus in clinical trials involving AD and PN by modulating neuroimmune pathways, improving skin integrity, and reducing inflammation . This Nemolizumab biosimilar is well suited for studying IL‑31 signaling, neuroimmune interactions in itch, barrier function, and the development of anti-pruritic therapeutics.

Specifications

Isotype Human IgG2, κ
Recommended Isotype Control(s) RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Mutations C130S/R132K/E136G/S137G/C218S/ H263Q/R350Q/Q414E/G441DEL/K442DEL
Immunogen Human IL-31RA
Reported Applications in vivo functional assays
in vitro functional assays
Flow cytometry
ELISA
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin ≤0.5EU/mg (≤0.0005EU/μg)
Determined by LAL gel clotting assay
Purity ≥95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant in an animal-free facility
Purification Protein A
Molecular Weight 150 kDa
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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