Catalog #SIM0124
InVivoSIM anti-human IL-23 (p19) (Risankizumab Biosimilar)
Clone
Risankizumab
Reactivities
Human
Applications
in vivo functional assays
in vitro functional assays
ELISA
in vitro functional assays
ELISA
Isotype
Human IgG1, κ
Product Description
This Risankizumab biosimilar antibody uses the same variable regions as the therapeutic antibody Risankizumab, making it ideal for research use. Risankizumab is a humanized IgG1 monoclonal antibody that specifically targets the p19 subunit of human interleukin-23 (IL-23), a pro-inflammatory cytokine involved in the differentiation, maintenance, and activation of Th17 cells. IL-23 is a heterodimeric cytokine composed of p19 and p40 subunits and plays a central role in regulating IL-17-mediated immune responses, chronic inflammation, and autoimmune disease. By selectively binding IL-23 p19, Risankizumab prevents IL-23 from interacting with its receptor complex, thereby inhibiting downstream JAK2/TYK2–STAT3 signaling and reducing IL-23-dependent inflammatory responses. Unlike antibodies targeting the shared p40 subunit of IL-12 and IL-23, Risankizumab selectively inhibits IL-23 without directly blocking IL-12 signaling. This selectivity makes it a valuable tool for distinguishing the contributions of IL-23 and IL-12 to immune regulation and inflammatory disease. This Risankizumab biosimilar is well suited for studying IL-23/Th17 signaling, T-cell differentiation, cytokine-mediated inflammation, psoriasis, inflammatory bowel disease, and autoimmune disease mechanisms, as well as for benchmarking the therapeutic antibody's target engagement and neutralizing activity in preclinical experimental systems.
Specifications
| Isotype | Human IgG1, κ |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG1 (LALA-PG) isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | L234A/L235A |
| Immunogen | Human IL-23 p19 |
| Reported Applications |
in vivo functional assays in vitro functional assays ELISA |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |