Catalog #SIM0121
InVivoSIM anti-human IL-17RA (Brodalumab biosimilar)
Clone
Brodalumab
Reactivities
Human
Applications
in vivo functional assays
in vitro functional assays
ELISA
Flow cytometry
in vitro functional assays
ELISA
Flow cytometry
Isotype
Human IgG2
Product Description
This biosimilar antibody uses the same variable regions as the therapeutic antibody Brodalumab, making it ideal for research use. Brodalumab is a human IgG2 monoclonal antibody that specifically targets interleukin-17 receptor A (IL-17RA), a key receptor that mediates signaling of multiple IL-17 family cytokines, including IL-17A, IL-17F, and IL-17A/F heterodimers. IL-17RA is broadly expressed on keratinocytes, epithelial cells, fibroblasts, and various immune cells, where it drives pro-inflammatory responses through activation of downstream pathways such as NF-κB. By binding to IL-17RA, Brodalumab blocks IL-17–mediated signaling, reducing the production of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. This pathway plays a central role in chronic inflammatory diseases, particularly psoriasis, where IL-17 signaling contributes to keratinocyte hyperproliferation and sustained inflammation. This Brodalumab biosimilar is well suited for studying IL-17 signaling, epithelial inflammation, and immune-mediated disease mechanisms.
Specifications
| Isotype | Human IgG2, κ |
|---|---|
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Immunogen | IL-17RA |
| Reported Applications |
in vivo functional assays in vitro functional assays ELISA Flow cytometry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |