Catalog #SIM0070
InVivoSIM anti-human IGF-1R (Teprotumumab Biosimilar)
Clone
Teprotumumab
Isotype
Human IgG1, κ
Product Description
This non‑therapeutic biosimilar antibody adopts the same variable regions as the therapeutic antibody Teprotumumab, making it ideal for research use. Teprotumumab is a fully human IgG1 monoclonal antibody that targets the insulin‑like growth factor‑1 receptor (IGF‑1R), a tyrosine kinase receptor broadly expressed across numerous cell types and prominently upregulated in thyroid eye disease (TED). In orbital fibroblasts, IGF‑1R forms functional complexes with the TSH receptor and drives pathogenic signaling cascades that lead to inflammation, tissue expansion, and remodeling in the orbit. IGF‑1R is activated by IGF‑1, a growth factor critical for regulating cell growth and tissue development both prenatally and postnatally. IGF‑1 promotes proliferation, migration, and differentiation in a wide variety of cell types and has broad metabolic functions, including regulation of glucose and lipid metabolism, modulation of steroid hormone signaling, and maintenance of cartilage and bone homeostasis. It also contributes to skeletal muscle regeneration and has been implicated in tumor progression and survival signaling in cancer. Teprotumumab binds the extracellular α-subunit of IGF‑1R, blocking receptor activation and downstream signaling via the PI3K/AKT and MAPK/ERK pathways, thus dampening inflammatory responses and reducing hyaluronan production and tissue remodeling.
Specifications
| Isotype | Human IgG1, κ |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG1 (LALA-PG) isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | E356D/M358L |
| Immunogen | Human IGF-1R |
| Reported Applications |
Functional assays Western blot Flow cytometry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |