InVivoSIM anti-human IgE (Omalizumab Biosimilar)

Catalog #SIM0016
Clone:
Omalizumab
Reactivities:
Human

$205.00 - $7,100.00

In stock
Only %1 left

Product Details

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Omalizumab making it ideal for research use. This Omalizumab biosimilar reacts with free human IgE in blood and interstitial fluid and to membrane-bound IgE on the surface of IgE-expressing B cells. It does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. It does not provoke histamine release from mast-cells sensitised by IgE. Omalizumab binds an epitope in proximity to the binding site of the FcεRI.

Specifications

Isotype Human IgG1, κ
Recommended Isotype Control(s) InVivoPlus human IgG1 isotype control
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen Human IgE
Reported Applications IgE neutralization
Flow cytometry
ELISA
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <1EU/mg (<0.001EU/μg)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by DLS
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 μM filtered
Production Purified from cell culture supernatant
Purification Protein A
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.