InVivoSIM anti-human FGFR2b (CD332) (Bemarituzumab Biosimilar)

Catalog #SIM0052
Clone:
Bemarituzumab
Reactivities:
Human

$235.00 - $8,140.00

$235.00 - $8,140.00

Choose an Option...
  • 100 mg - $8,140.00
  • 50 mg - $4,574.00
  • 25 mg - $3,182.00
  • 5 mg - $911.00
  • 1 mg - $235.00
  • Custom Amount (Quotes Only)
In stock
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Product Details

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody, Bemarituzumab, making it ideal for research use. Bemarituzumab is a humanized IgG1Īŗ anti-human FGFR2b (CD332) antibody, which reacts with the fibroblast growth factor receptor 2 IIIb isoform (FGFR2b) of FGFR2. FGFR2 is a member of a family of four FGF receptors that interact with over 20 different fibroblast growth factors (FGFs), each of which shows relatively unique and restricted expression to specific tissues, cell types, and/or developmental stages. FGF7, FGF10, and FGF22 are the main ligands of FGFR2b. FGFR2b is expressed in epithelial tissues such as the stomach and skin and is often found overexpressed in gastric cancers. FGF-FGFR2 signaling is involved in many cancers, such as gastric, breast, ovarian, endometrial, lung, and bile duct cancers. Bemarituzumab has recently been introduced for the therapeutic blockade of FGFR2b signaling. In combination with anti-cancer experimental therapeutics, bemarituzumab is documented to exhibit substantial synergism in vivo with immune checkpoint blockage via anti-PD-1 or chemotherapy.

NOTE: The CHOK1BN-Fut8KO cell line was not used to express this bemarituzumab antibody (SIM0052), so it is NOT afucosylated.

Specifications

Isotype Human IgG1, Īŗ
Recommended Isotype Control(s) RecombiMAb human IgG1 (K214R/L234F/L235E/P331S) isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Mutations K214R
Immunogen Human FGFR2b
Reported Applications in vivo functional assays
in vitro functional assays
Flow cytometry
ELISA
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <0.5EU/mg (<0.0005EU/Ī¼g)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by SEC
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 Āµm filtration
Production Purified from cell culture supernatant in an animal-free facility
Purification Protein A
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theilerā€™s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze.