InVivoSIM anti-human FcRn (FCGRT) (Nipocalimab Biosimilar)

Catalog #SIM0062
Clone:
Nipocalimab
Reactivities:
Human

$235.00 - $8,140.00

$235.00 - $8,140.00

Choose an Option...
  • 100 mg - $8,140.00
  • 50 mg - $4,574.00
  • 25 mg - $3,182.00
  • 5 mg - $911.00
  • 1 mg - $235.00
  • Custom Amount (Quotes Only)
In stock
Only %1 left

Product Details

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Nipocalimab, making it ideal for research use. Nipocalimab is a fully human IgG1 monoclonal antibody that targets the neonatal Fc receptor (FcRn), a key regulator of IgG homeostasis and recycling. FcRn binds to IgG antibodies at acidic pH in endosomes and protects them from lysosomal degradation by recycling them back to the cell surface, where they are released at neutral pH. This process extends the half-life of circulating IgG antibodies. FcRn is expressed in a variety of cell types, including endothelial cells, epithelial cells (such as those in the lung, intestine, and placenta), monocytes, macrophages, dendritic cells, and neutrophils. Its widespread expression supports systemic IgG regulation, tissue-level antibody transport, and immune homeostasis. By binding to FcRn, Nipocalimab competitively inhibits endogenous IgG from interacting with FcRn, thereby accelerating IgG catabolism and reducing total IgG levels in circulation. This mechanism has therapeutic implications for IgG-mediated autoimmune diseases, where pathogenic autoantibodies contribute to disease pathology. This Nipocalimab biosimilar antibody is intended for non-therapeutic research use only and is an excellent tool for studying FcRn biology, IgG clearance, antibody recycling, and the development of FcRn-targeting therapeutics.

Specifications

Isotype Human IgG1, Ī»
Recommended Isotype Control(s) RecombiMAb human IgG1 (N297A) isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Mutations N297A/KDel
Immunogen Human FcRn
Reported Applications Functional assays
Flow cytometry
ELISA
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <0.5EU/mg (<0.0005EU/μg)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by SEC
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant in an animal-free facility
Purification Protein A
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.