Catalog #SIM0100
InVivoSIM anti-human CLEVER-1 (Bexmarilimab biosimilar)
Clone
Bexmarilimab
Reactivities
Human
Applications
in vivo functional assays
in vitro functional assays
ELISA
Flow cytometry
in vitro functional assays
ELISA
Flow cytometry
Isotype
Human IgG4, κ
Product Description
This biosimilar Bexmarilimab antibody uses the same variable regions as the therapeutic antibody Bexmarilimab, making it ideal for research use. Bexmarilimab is a humanized IgG4 monoclonal antibody that targets Clever-1 (also known as Stabilin-1; STAB1), a scavenger receptor expressed on immunosuppressive myeloid cells including circulating monocytes and tumor-associated macrophages (TAMs), as well as on subsets of vascular and sinusoidal endothelium. Clever-1 contributes to immune suppression by promoting scavenging and endocytic programs that can dampen inflammatory activation and antigen presentation. By binding and blocking Clever-1, Bexmarilimab is designed to reprogram macrophages toward a more pro-inflammatory, immune-stimulatory phenotype, enhancing antigen presentation and supporting T-cell activation within the tumor microenvironment. Clinically, Bexmarilimab has been investigated in both solid tumors and hematologic malignancies as a macrophage-reprogramming immunotherapy, including in combination regimens. This Bexmarilimab biosimilar is well suited for studying Clever-1/STAB1 biology, macrophage polarization and antigen presentation, tumor-associated inflammation, immune suppression in the tumor microenvironment, and for benchmarking the therapeutic antibody’s mechanism of action in pre-clinical experimental systems.
Specifications
| Isotype | Human IgG4, κ |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG4 (S228P) isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | S228P/L235E |
| Immunogen | Human CLEVER-1 |
| Reported Applications |
in vivo functional assays in vitro functional assays ELISA Flow cytometry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |