InVivoSIM anti-human Claudin 18.2 (Zolbetuximab Biosimilar)

Catalog #SIM0026
Clone:
Zolbetuximab
Reactivities:
Human

$217.00 - $7,526.00

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  • 100 mg - $7,526.00
  • 50 mg - $4,229.00
  • 25 mg - $2,942.00
  • 5 mg - $843.00
  • 1 mg - $217.00
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Product Details

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Zolbetuximab making it ideal for research use. This Zolbetuximab biosimilar antibody reacts with isoform 2 of human claudin 18. Claudin 18.2, a member of the claudin family, is commonly expressed in multiple cancers, including gastric and pancreatic cancer. Claudin 18.2 is not expressed in any healthy tissues except for gastric mucosa. Claudins play a major role in tight junctions which establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. They also play an important role in tumorigenesis and inflammation. Alterations in claudin expression have been shown to lead to impaired functions of tight junctions, influence signaling pathways, and act as tumor promoting events in some epithelial cancers. In a humanized mouse model of prostate cancer Zolbetuximab demonstrated antitumor activity by stimulating ADCC and/or CDC.

Specifications

Isotype Human IgG1, κ
Recommended Isotype Control(s) InVivoPlus human IgG1 isotype control
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen Human claudin 18.2
Reported Applications Functional assays
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <1EU/mg (<0.001EU/μg)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by SEC
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from tissue culture supernatant in an animal free facility
Purification Protein A
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.