InVivoSIM anti-human CEACAM6 (Tinurilimab Biosimilar)

Catalog #SIM0063
Clone:
Tinurilimab
Reactivities:
Human

$235.00 - $8,140.00

$235.00 - $8,140.00

Choose an Option...
  • 100 mg - $8,140.00
  • 50 mg - $4,574.00
  • 25 mg - $3,182.00
  • 5 mg - $911.00
  • 1 mg - $235.00
  • Custom Amount (Quotes Only)
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Product Details

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Tinurilimab making it ideal for research use. Tinurilimab is a humanized IgG2 monoclonal antibody that targets CEACAM6 (CD66c), a member of the carcinoembryonic antigen-related cell adhesion molecule family. CEACAM6 is overexpressed in various epithelial cancers, including non-small cell lung cancer (NSCLC), pancreatic, gastric, colorectal, and breast cancers, and is associated with tumor progression and poor prognosis. CEACAM6 functions as an immune checkpoint regulator, suppressing the activity of effector T-cells against tumors. By binding to CEACAM6, Tinurilimab may enhance anti-tumor immune responses by relieving this suppression. Additionally, CEACAM6 contributes to epithelial-mesenchymal transition (EMT), invasion, and metastasis, making it a valuable target for cancer research. This biosimilar antibody is well-suited for studies involving CEACAM6-mediated signaling, tumor immunology, and the development of CEACAM6-targeted therapies.

Specifications

Isotype Human IgG2, Īŗ
Recommended Isotype Control(s) RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Mutations KDel
Immunogen Human CEACAM6
Reported Applications Functional assays
ELISA
Immunohistochemistry
Western blot
Flow cytometry
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <0.5EU/mg (<0.0005EU/μg)
Determined by LAL gel clotting assay
Aggregation <5%
Determined by SEC
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant in an animal-free facility
Purification Protein A
Molecular Weight 150 kDa
Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.