Catalog #SIM0063
InVivoSIM anti-human CEACAM6 (Tinurilimab Biosimilar)
Clone
Tinurilimab
Reactivities
Human
Isotype
Human IgG2, κ
Product Description
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Tinurilimab making it ideal for research use. Tinurilimab is a humanized IgG2 monoclonal antibody that targets CEACAM6 (CD66c), a member of the carcinoembryonic antigen-related cell adhesion molecule family. CEACAM6 is overexpressed in various epithelial cancers, including non-small cell lung cancer (NSCLC), pancreatic, gastric, colorectal, and breast cancers, and is associated with tumor progression and poor prognosis. CEACAM6 functions as an immune checkpoint regulator, suppressing the activity of effector T-cells against tumors. By binding to CEACAM6, Tinurilimab may enhance anti-tumor immune responses by relieving this suppression. Additionally, CEACAM6 contributes to epithelial-mesenchymal transition (EMT), invasion, and metastasis, making it a valuable target for cancer research. This biosimilar antibody is well-suited for studies involving CEACAM6-mediated signaling, tumor immunology, and the development of CEACAM6-targeted therapies.
Specifications
| Isotype | Human IgG2, κ |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | KDel |
| Immunogen | Human CEACAM6 |
| Reported Applications |
Functional assays ELISA Immunohistochemistry Western blot Flow cytometry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |