InVivoSIM anti-human CD38 (Isatuximab Biosimilar)
Catalog #SIM0092
Clone:
Isatuximab
Reactivities:
Human
Product Details
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Isatuximab, making it ideal for research use. Isatuximab is a chimeric IgG1 monoclonal antibody that specifically targets human CD38, a multifunctional transmembrane glycoprotein highly expressed on malignant plasma cells and other hematologic tumor cells, but also found at lower levels on subsets of immune cells such as NK cells, regulatory T cells, B cells, and some myeloid cells. CD38 has both receptor and ectoenzyme functions, contributing to cell adhesion, signal transduction, calcium mobilization, and NAD+ metabolism. By binding CD38, Isatuximab induces tumor cell death through multiple mechanisms including antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP), and direct pro-apoptotic signaling. In the clinic, Isatuximab is approved for the treatment of multiple myeloma, where it has shown efficacy in reducing tumor burden and extending survival when combined with standard-of-care therapies. This Isatuximab biosimilar is well suited for studying CD38 signaling, plasma cell biology, tumor immunology, immune regulation, and therapeutic strategies targeting multiple myeloma and other CD38-positive malignancies.Specifications
| Isotype | Human IgG1, Īŗ |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | E356D/M358L |
| Immunogen | Human CD38 |
| Reported Applications |
in vivo functional assays in vitro functional assays ELISA Flow cytometry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
<0.5EU/mg (<0.0005EU/Ī¼g) Determined by LAL gel clotting assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
>95% Determined by SDS-PAGE |
| Sterility | 0.2 Āµm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theilerās Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze. |
Recommended Products
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Recommended Isotype Control(s)
RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer