Catalog #SIM0092
InVivoSIM anti-human CD38 (Isatuximab Biosimilar)
Clone
Isatuximab
Reactivities
Human
Isotype
Human IgG1, κ
Product Description
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Isatuximab, making it ideal for research use. Isatuximab is a chimeric IgG1 monoclonal antibody that specifically targets human CD38, a multifunctional transmembrane glycoprotein highly expressed on malignant plasma cells and other hematologic tumor cells, but also found at lower levels on subsets of immune cells such as NK cells, regulatory T cells, B cells, and some myeloid cells. CD38 has both receptor and ectoenzyme functions, contributing to cell adhesion, signal transduction, calcium mobilization, and NAD+ metabolism. By binding CD38, Isatuximab induces tumor cell death through multiple mechanisms including antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP), and direct pro-apoptotic signaling. In the clinic, Isatuximab is approved for the treatment of multiple myeloma, where it has shown efficacy in reducing tumor burden and extending survival when combined with standard-of-care therapies. This Isatuximab biosimilar is well suited for studying CD38 signaling, plasma cell biology, tumor immunology, immune regulation, and therapeutic strategies targeting multiple myeloma and other CD38-positive malignancies.
Specifications
| Isotype | Human IgG1, κ |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | E356D/M358L |
| Immunogen | Human CD38 |
| Reported Applications |
in vivo functional assays in vitro functional assays ELISA Flow cytometry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |