Catalog #SIM0106
InVivoSIM anti-human CD37 (Otlertuzumab biosimilar)
Clone
Otlertuzumab
Reactivities
Human
Isotype
ScFv-Human IgG1 Fc (E356D/M358L)
Product Description
The biosimilar Otlertuzumab antibody uses the same variable regions as the therapeutic molecule Otlertuzumab, making it ideal for research use. Otlertuzumab is an ScFv with human IGG1 Fc containing E356D/M358L CD37-targeting protein therapeutic that binds human CD37, a tetraspanin protein highly expressed on mature B cells and B cell malignancies, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma. CD37 plays a role in B cell survival, proliferation, and signaling. By binding to CD37, Otlertuzumab induces direct apoptotic signaling and mediates immune effector functions, including antibody-dependent cellular cytotoxicity (ADCC). This Otlertuzumab biosimilar is well suited for studying CD37 biology, B cell malignancies, and mechanisms of targeted B cell depletion and apoptosis.
Specifications
| Isotype | ScFv-Human IgG1 Fc (E356D/M358L) |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG1 (E356D/M358L) isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | E356D/M358L |
| Immunogen | Human CD37 |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| RRID | AB_3751725 |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |