InVivoSIM anti-human CD3 x BCMA (Teclistamab Biosimilar)
Catalog #SIM0067
Clone:
Teclistamab
Reactivities:
Human
Product Details
This non-therapeutic biosimilar antibody utilizes the same variable regions as the therapeutic antibody Teclistamab, making it ideal for research use. Teclistamab is a humanized IgG4 bispecific monoclonal antibody that targets both B-cell maturation antigen (BCMA) on malignant plasma cells and CD3Īµ on T cells. BCMA is predominantly expressed on plasma cells and plays a crucial role in their survival and proliferation. By simultaneously binding to BCMA and CD3, Teclistamab redirects T cells to recognize and eliminate BCMA-expressing multiple myeloma cells through T-cell activation and subsequent cytotoxicity. The Fc region of Teclistamab contains S228P/L234A/L235A mutations to minimize its immunological effector functions. This biosimilar antibody is a valuable tool for studying T-cell engagement, bispecific antibody mechanisms, and BCMA-targeted therapies.Specifications
| Isotype | Human IgG4, Ī» |
|---|---|
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | S228P/F234A/L235A |
| Immunogen | Human BCMA-Fc recombinant protein |
| Reported Applications |
Functional assays Flow cytometry ELISA Immunohistochemistry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
<0.5EU/mg (<0.0005EU/Ī¼g) Determined by LAL gel clotting assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
>95% Determined by SDS-PAGE |
| Sterility | 0.2 Āµm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theilerās Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze. |
Recommended Products
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer