Catalog #SIM0067
InVivoSIM anti-human CD3 x BCMA (Teclistamab Biosimilar)
Clone
Teclistamab
Reactivities
Human
Isotype
Human IgG4, λ
Product Description
This non-therapeutic biosimilar antibody utilizes the same variable regions as the therapeutic antibody Teclistamab, making it ideal for research use. Teclistamab is a humanized IgG4 bispecific monoclonal antibody that targets both B-cell maturation antigen (BCMA) on malignant plasma cells and CD3ε on T cells. BCMA is predominantly expressed on plasma cells and plays a crucial role in their survival and proliferation. By simultaneously binding to BCMA and CD3, Teclistamab redirects T cells to recognize and eliminate BCMA-expressing multiple myeloma cells through T-cell activation and subsequent cytotoxicity. The Fc region of Teclistamab contains S228P/L234A/L235A mutations to minimize its immunological effector functions. This biosimilar antibody is a valuable tool for studying T-cell engagement, bispecific antibody mechanisms, and BCMA-targeted therapies.
Specifications
| Isotype | Human IgG4, λ |
|---|---|
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | S228P/F234A/L235A |
| Immunogen | Human BCMA-Fc recombinant protein |
| Reported Applications |
Functional assays Flow cytometry ELISA Immunohistochemistry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |