InVivoSIM anti-human ActRIIA (ACVR2A), ActRIIB (ACVR2B) (Bimagrumab Biosimilar)
Catalog #SIM0086
Clone:
Bimagrumab
Reactivities:
Human
Product Details
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Bimagrumab, making it ideal for research use. Bimagrumab is a fully human IgG1 monoclonal antibody that targets the activin type II receptors ActRIIA (ACVR2A) and ActRIIB (ACVR2B), which are members of the TGF-Ī² receptor superfamily. ActRIIA and ActRIIB are broadly expressed on skeletal muscle cells and other tissues, where they mediate signaling of myostatin, activins, and related ligands. These signaling pathways normally limit muscle growth and contribute to muscle wasting in a variety of pathological settings. By binding to and blocking ActRIIA/ActRIIB, Bimagrumab inhibits ligandāreceptor interactions, thereby releasing the inhibitory brake on muscle growth and promoting hypertrophy. In clinical studies, Bimagrumab has been shown to increase lean body mass and muscle strength in patients with sarcopenia, cancer cachexia, and neuromuscular disorders, although its therapeutic development has focused primarily on muscle wasting diseases and metabolic disorders such as obesity and type 2 diabetes. This Bimagrumab biosimilar is well suited for investigating TGF-Ī² family receptor signaling, muscle biology, sarcopenia, cachexia, obesity, and therapeutic approaches aimed at enhancing muscle mass and metabolic health.Specifications
| Isotype | Human IgG1, Īŗ |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG1 (LALA-PG) isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | LALA-PG |
| Immunogen | Human ActRIIA and ActRIIB |
| Reported Applications |
In vivo functional assays in vitro functional assays Flow cytometry ELISA |
| Formulation |
pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
<0.5EU/mg (<0.0005EU/Ī¼g) Determined by LAL gel clotting assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
>95% Determined by SDS-PAGE |
| Sterility | 0.2 Āµm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theilerās Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze. |
Recommended Products
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Recommended Isotype Control(s)
RecombiMAb human IgG1 (LALA-PG) isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer