Catalog #CPB530
Bispecific anti-mouse TL1A (TNFSF15) x anti-mouse IL23p19 (LALA-PG) - PREORDER
Clone
derived from clones 5G4.6 and G23-8
Reactivities
Mouse
Isotype
mouse IgG2a (LALA-PG), κ
Product Description
CPB530 is a 1+1 bivalent bispecific designed to simultaneously target mouse TL1A (TNFSF15) and mouse IL23p19. CPB530 contains a murine IgG2a constant region to reduce immunogenicity and the formation of anti-drug antibodies (ADAs) in mouse models and LALA-PG Fc-silencing mutations to abolish antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) while minimizing Fc-driven off-target toxicity and depletion of checkpoint‑expressing effector T cells. This bispecific was designed to bind and inhibit two independent, yet convergent, pathogenic drivers of the inflammatory environment. Blocking TL1A prevents the amplification of T-cell responses and inhibits the production of pro-inflammatory cytokines such as IFN-γ and IL-17. Inhibiting the p19 subunit of IL-23 prevents the activation of the IL-23 receptor (IL-23R) and subsequent downstream signaling that drives the expansion and survival of pathogenic T cells. By preventing the synergistic activation of T cells by both IL-23 and TL1A, bispecific antibodies effectively dampen the inflammatory cascade and help restore immune homeostasis in affected tissues.
Specifications
| Isotype | Mouse IgG2a (LALA-PG), κ |
|---|---|
| Recommended Isotype Control(s) | Bispecific mouse IgG2a (LALA-PG), kappa isotype control |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | LALA-PG |
| Reported Applications |
ELISA For information on in-vivo applications, please contact technicalservice@bioxcell.com |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from mammalian cell supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 147 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |