Catalog #SIM0016
InVivoSIM anti-human IgE (Omalizumab Biosimilar)
Clone
Omalizumab
Reactivities
Human
Isotype
Human IgG1, κ
Product Description
This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Omalizumab making it ideal for research use. This Omalizumab biosimilar reacts with free human IgE in blood and interstitial fluid and to membrane-bound IgE on the surface of IgE-expressing B cells. It does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. It does not provoke histamine release from mast-cells sensitised by IgE. Omalizumab binds an epitope in proximity to the binding site of the FcεRI.
Specifications
| Isotype | Human IgG1, κ |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Human IgE |
| Reported Applications |
IgE neutralization Flow cytometry ELISA |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Purification | Protein A |
| RRID | AB_2927532 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |