Catalog #CPB506
Bispecific anti-mouse LAG3 x anti-mouse CTLA-4 - PREORDER
Clone
Derived from clones C9B7W and 9D9
Reactivities
Mouse
Isotype
mouse IgG2a (LALA-PG), κ
Product Description
CPB506 is a 1+1 bivalent bispecific checkpoint inhibitor antibody designed to target mouse lymphocyte-activation gene 3 (LAG3) and mouse cytotoxic T‑lymphocyte–associated antigen‑4 (CTLA-4). CPB506 contains the murine IgG2a constant region to reduce immunogenicity and the formation of anti-drug antibodies (ADAs) in mouse models and LALA-PG Fc-silencing mutations to abolish antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) while minimizing Fc-driven off-target toxicity. CTLA‑4 blockade reduces competition with CD28 for CD80/CD86, enhancing costimulatory signaling and promoting expansion and priming of effector T cells. LAG‑3 is upregulated on chronically stimulated T cells and many intratumoral Tregs, where it dampens TCR signaling and contributes to exhaustion and reduced cytokine production. CPB506 is designed to simultaneously block two distinct inhibitory receptors and enrich bispecific concentration and potency to dual‑positive cells in the tumor microenvironment to reinvigorate dysfunctional T cells and enhance antitumor T‑cell responses while limiting systemic toxicity.
Specifications
| Isotype | Mouse IgG2a (LALA-PG), κ |
|---|---|
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | LALA-PG |
| Reported Applications |
ELISA For information on in-vivo applications, please contact technicalservice@bioxcell.com |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| Purity |
≥95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from mammalian cell supernatant in an animal-free facility |
| Molecular Weight | 135.7 |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Need a Custom Formulation? | See All Antibody Customization Options |