InVivoSIM anti-human CD3 x GPRC5D (Talquetamab Biosimilar)
Catalog #SIM0069
Clone:
Talquetamab
Reactivities:
Human
Product Details
This nonātherapeutic bispecific biosimilar antibody uses the same variable regions as the therapeutic bispecific Talquetamab, making it ideal for research use. Talquetamab is a humanized IgG4 bispecific Tācell engager (BiTE) that targets GPRC5D, a receptor highly expressed on multiple myeloma cells, and CD3Īµ on T cells. It redirects T cells to form a cytotoxic synapse with GPRC5D-positive tumor cells, triggering perforin- and granzyme-mediated apoptosis of malignant plasma cells.Specifications
| Isotype | Human IgG4, Īŗ |
|---|---|
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Mutations | S228P/F234A/L235A |
| Reported Applications |
Functional assays Flow cytometry ELISA Immunohistochemistry |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
<0.5EU/mg (<0.0005EU/Ī¼g) Determined by LAL gel clotting assay |
| Aggregation |
<5% Determined by SEC |
| Purity |
>95% Determined by SDS-PAGE |
| Sterility | 0.2 Āµm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theilerās Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze. |
Recommended Products
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer